血清素合成阻断对大鼠脑内白细胞介素-1β作用的影响。
Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats.
作者信息
Zubareva O E, Krasnova I N, Abdurasulova I N, Bluthe R M, Dantzer R, Klimenko V M
机构信息
Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia.
出版信息
Brain Res. 2001 Oct 12;915(2):244-7. doi: 10.1016/s0006-8993(01)02910-9.
The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.
研究了大脑血清素能系统介导白细胞介素-1β（IL-1β）作用的能力。向大鼠脑室内注射IL-1β可引起明显的发热反应、社交行为减退、体重减轻和食物摄入量减少。用对氯苯丙氨酸（一种血清素合成抑制剂）进行预处理，可阻断IL-1β引起的食物摄入量减少和体重减轻，但未能改变体温升高和交流活动减少的情况。
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