Katz R S, Baker D H
J Nutr. 1975 Sep;105(9):1168-75. doi: 10.1093/jn/105.9.1168.
Several assays with young chicks fed crystalline amino acid diets were conducted to investigate the effects of supplemental glycine, serine, threonine, arginine, or adenine on the growth depression resulting from consumption of excess methionine. Glycine was partially effective in alleviating the growth depression caused by excess methionine. The addition of threonine together with glycine improved performance still further. Efficiency of food utilization for weight gain was greater in birds fed the methionine-imbalanced diet supplemented with glycine and threonine than in those fed the control diet. Supplemental glycine, threonine, or adenine, but not arginine, was effective in ameliorating the hypoglycemia resulting from consumption of excess methionine. The rate of oxidation of a tracer dose of threonine was increased markedly by feeding 1.25% excess methionine. This was reflected in a 20% depression in threonine utilization for weight gain as measured by slope ratio. The data suggest that both threonine and glycine are antagonized by consumption of excess methionine.
用饲喂结晶氨基酸日粮的幼雏进行了多项试验，以研究补充甘氨酸、丝氨酸、苏氨酸、精氨酸或腺嘌呤对因摄入过量蛋氨酸而导致的生长抑制的影响。甘氨酸在缓解过量蛋氨酸引起的生长抑制方面有部分效果。苏氨酸与甘氨酸一起添加可进一步改善生长性能。与饲喂对照日粮的鸟类相比，饲喂补充了甘氨酸和苏氨酸的蛋氨酸不平衡日粮的鸟类，其用于体重增加的食物利用效率更高。补充甘氨酸、苏氨酸或腺嘌呤（但不是精氨酸）可有效改善因摄入过量蛋氨酸而导致的低血糖。饲喂1.25%过量蛋氨酸可使示踪剂量苏氨酸的氧化速率显著增加。这反映在通过斜率比测量的用于体重增加的苏氨酸利用率降低了20%。数据表明，过量蛋氨酸的摄入会拮抗苏氨酸和甘氨酸。
