Tsukimi Y, Ogawa T, Okabe S
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan.
J Physiol Paris. 2001 Jan-Dec;95(1-6):221-8. doi: 10.1016/s0928-4257(01)00029-8.
Wine apparently stimulates gastric acid secretion both in man and animals, yet the underlying mechanism remains unclear. The present study was attempted to clarify the pharmacological properties involved in gastric acid secretion stimulated by wine in beagle dogs. Commercially available red or white wine, 14% ethanol, or 10% peptone meal was intragastrically administered to dogs with vagally denervated Heidenhain pouches. Gastric acid secretion was stimulated by both red and white wines (25-50 ml) for 45-60 min. While S-0509 only tended to inhibit wine-stimulated gastric acid secretion, both atropine and famotidine significantly inhibited wine-stimulated gastric acid secretion. Plasma gastrin level was not significantly increased by administration of red and white wines. Administration of 14% ethanol also stimulated gastric acid secretion, but the effect was about half of that of wine. Combined administration of wine and peptone resulted in a biphasic stimulation of gastric acid secretion. S-0509, atropine and famotidine significantly inhibited wine+peptone meal stimulation, yet the order of inhibition of cumulative acid secretion was in the order, famotidine>atropine>S-0509. It was concluded that wine stimulated gastric acid secretion in denervated dogs via acethylcholine- and histamine-dependent mechanisms, but nearly independent from the intervention of gastrin.
葡萄酒显然会刺激人和动物的胃酸分泌，但其潜在机制仍不清楚。本研究旨在阐明比格犬中葡萄酒刺激胃酸分泌所涉及的药理学特性。将市售的红葡萄酒或白葡萄酒、14%乙醇或10%蛋白胨溶液经胃内给予具有迷走神经切断的海登海因小胃的犬。红葡萄酒和白葡萄酒（25 - 50毫升）均刺激胃酸分泌45 - 60分钟。虽然S - 0509仅倾向于抑制葡萄酒刺激的胃酸分泌，但阿托品和法莫替丁均显著抑制葡萄酒刺激的胃酸分泌。给予红葡萄酒和白葡萄酒后，血浆胃泌素水平没有显著升高。给予14%乙醇也会刺激胃酸分泌，但其作用约为葡萄酒的一半。葡萄酒和蛋白胨联合给药导致胃酸分泌呈双相刺激。S - 0509、阿托品和法莫替丁均显著抑制葡萄酒 + 蛋白胨溶液刺激，但累积胃酸分泌的抑制顺序为法莫替丁>阿托品>S - 0509。得出的结论是，葡萄酒通过乙酰胆碱和组胺依赖性机制刺激去神经支配犬的胃酸分泌，但几乎独立于胃泌素的干预。
