了解白喉毒素的作用模式：20世纪进展透视
Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century.
作者信息
Collier R J
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Toxicon. 2001 Nov;39(11):1793-803. doi: 10.1016/s0041-0101(01)00165-9.
Abstract
Diphtheria toxin is one of the most extensively studied and well understood bacterial toxins. Ever since its discovery in the late 1800's this toxin has occupied a central focus in the field of toxinology. In this review, I present a chronology of major discoveries that led to our current understanding of the structure and activity of diphtheria toxin.
摘要
白喉毒素是研究最为广泛且理解最为透彻的细菌毒素之一。自19世纪末被发现以来，这种毒素一直是毒素学领域的核心研究对象。在这篇综述中，我将按时间顺序呈现一系列重大发现，正是这些发现使我们对白喉毒素的结构和活性有了当前的认识。
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