基于聚（β-氨基酯）的纳米载体：结构调控与基因递送
Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery.
作者信息
Zhang Jiayu, Cai Xiaomeng, Dou Rui, Guo Chen, Tang Jiaruo, Hu Yi, Chen Hanqing, Chen Jun
机构信息
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics and University of Chinese Academy of Sciences (UCAS), Chinese Academy of Sciences (CAS), Beijing 100049, P. R. China.
Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China.
出版信息
Mol Ther Nucleic Acids. 2023 Apr 23;32:568-581. doi: 10.1016/j.omtn.2023.04.019. eCollection 2023 Jun 13.
The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.
首批聚（β-氨基）酯（PβAEs）是在40多年前合成的。自2000年以来，人们发现PβAEs具有出色的生物相容性和运载基因分子的能力。此外，PβAEs的合成过程简单，单体易于获得，并且可以通过调整单体类型、单体比例、反应时间等对聚合物结构进行定制，以满足不同的基因递送需求。因此，PβAEs是一类很有前景的非病毒基因载体材料。本文综述全面概述了PβAEs的合成及其相关性质，并总结了每种类型PβAEs用于基因递送的进展。该综述特别关注PβAE结构的合理设计，深入讨论内在结构与效果之间的相关性，最后介绍了PβAEs的应用和前景。
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