Tan K L
J Pediatr. 1975 Oct;87(4):609-12. doi: 10.1016/s0022-3476(75)80837-7.
The relative effectiveness of phototherapy and exchange transfusion for nonhemolytic neonatal hyperbilirubinemia was compared in two closely matched groups of infants. Although the exchange transfusion achieved an immediate reduction of bilirubin level, the "rebound" was rapid and tended to offset this reduction. The more gradual and steady effect of phototherapy resulted in a significantly lower serum bilirubin level at 1, 2, and 3 days after commencement of therapy; the rebound after phototherapy was small. Phototherapy was demonstrated to be more effective than exchange transfusion in achieving prolonged reduction of bilirubin levels for nonhemolytic hyperbilirubinemia. With more efficient lamps delivering more energy in the desired spectrum, it would seem feasible to treat hyperbilirubinemia of whatever etiology with this safer and more convenient form of therapy, though sometimes only as in adjunct therapy.
在两组密切匹配的婴儿中比较了光疗和换血疗法对非溶血性新生儿高胆红素血症的相对疗效。尽管换血疗法能使胆红素水平立即降低，但“反弹”迅速，往往抵消了这种降低。光疗的效果更为渐进和稳定，在治疗开始后的第1、2和3天，血清胆红素水平显著降低；光疗后的反弹很小。结果表明，在实现非溶血性高胆红素血症胆红素水平的长期降低方面，光疗比换血疗法更有效。随着更高效的灯在所需光谱中传递更多能量，用这种更安全、更方便的治疗方式治疗任何病因的高胆红素血症似乎都是可行的，尽管有时仅作为辅助治疗。
