Crowe J E
Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Clin Infect Dis. 2001 Nov 15;33(10):1720-7. doi: 10.1086/322971. Epub 2001 Oct 5.
Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but seropositive to the viral agents because they possess maternal IgG antibodies (Abs). Transplacental maternal Abs may be partially protective against disease caused by respiratory virus infections. Carefully conducted studies have shown that these Abs can also profoundly suppress or enhance infant immune responses to immunization. The mechanisms underlying regulation of immune responses to viruses by maternal Abs are under investigation. This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression.
由于因这些病毒住院的患者年龄较小，成功预防严重婴儿呼吸道病毒疾病的疫苗应在非常小的年龄就诱导产生保护作用。候选呼吸道病毒疫苗正在未感染过但对病毒抗原血清阳性的婴儿中进行测试，因为他们拥有母体IgG抗体（Abs）。经胎盘的母体抗体可能对呼吸道病毒感染引起的疾病有部分保护作用。精心开展的研究表明，这些抗体也能深刻抑制或增强婴儿对免疫接种的免疫反应。母体抗体对病毒免疫反应调节的潜在机制正在研究中。本文探讨了关于母体抗体对呼吸道病毒和麻疹病毒免疫接种影响的现有知识，并综述了克服抗体介导的免疫抑制的当前方法。
