Tanaka N, Ogi K, Odajima T, Dehari H, Yamada S, Sonoda T, Kohama G
Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Cancer. 2001 Oct 15;92(8):2117-25. doi: 10.1002/1097-0142(20011015)92:8<2117::aid-cncr1553>3.0.co;2-o.
pRb2/p130 is one of the retinoblastoma (Rb) gene family and a suppressor oncogene. Immunohistochemically, the expression of pRb2/p130 was reported to be correlated inversely with the degree of malignancy in lung carcinoma and endometrial carcinoma. In the current study, the correlation between expression of pRb2/p130 and clinicopathologic factors in oral squamous cell carcinoma was investigated.
One hundred twenty-two specimens from patients with oral squamous cell carcinoma were investigated by staining with a polyclonal antibody against pRb2/p130. The correlation between the expression of pRb2/p130 and various clinicopathologic factors was studied.
Positive staining for pRb2/p130 was observed in 61 of 122 cases (50.0%). pRb2/p130 expression was found to be correlated significantly with clinical stage (P = 0.050), cervical lymph node metastasis (P = 0.035), and tumor differentiation (P = 0.050). In the entire group a significantly reduced 5-year cumulative survival rate was observed in patients with pRb2/p130-negative tumors compared with patients whose tumors positively expressed pRb2/p130 (P = 0.0004). When tested with Cox proportional hazards regression analysis, the most significant independent prognostic factor for the entire group of 122 patients was found to be pRb2/p130 expression.
Expression of pRb2/p130 may be a good prognostic indicator in patients with oral squamous cell carcinoma and also may be utilized for the subclassification of tumors with the Grade 3 mode of carcinoma invasion.
pRb2/p130是视网膜母细胞瘤（Rb）基因家族之一，是一种抑癌基因。免疫组化研究表明，pRb2/p130的表达与肺癌和子宫内膜癌的恶性程度呈负相关。在本研究中，我们调查了pRb2/p130的表达与口腔鳞状细胞癌临床病理因素之间的相关性。
采用抗pRb2/p130多克隆抗体对122例口腔鳞状细胞癌患者的标本进行染色，研究pRb2/p130的表达与各种临床病理因素之间的相关性。
122例病例中有61例（50.0%）pRb2/p130染色呈阳性。发现pRb2/p130表达与临床分期（P = 0.050）、颈部淋巴结转移（P = 0.035）和肿瘤分化（P = 0.050）显著相关。在整个研究组中，与pRb2/p130阳性肿瘤患者相比，pRb2/p130阴性肿瘤患者的5年累积生存率显著降低（P = 0.0004）。当用Cox比例风险回归分析进行检验时，发现122例患者整个研究组中最显著的独立预后因素是pRb2/p130表达。
pRb2/p130的表达可能是口腔鳞状细胞癌患者的一个良好预后指标，也可用于具有3级癌浸润模式肿瘤的亚分类。
