Wang P, Xu J H, Wei E Q
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Zhejiang Medical University, Hangzhou 310031.
Yao Xue Xue Bao. 1997 Dec;32(12):888-92.
The anti-anaphylactic action of potassium channel openers was studied and reported in this paper. Minoxidil(Min) was shown to inhibit passive cutaneous anaphylaxis in rats. Diazoxide (Dia) and Min were found to inhibit antigen-induced guinea-pig ileum smooth muscle contraction in vitro. Min was shown to antagonize 5-HT-induced capillary permeability in rat skin. Dia was demonstrated to inhibit histamine release from rat peritoneal mast cells induced by A23187 and compound 48/80, but it failed to antagonize guinea-pig ileum smooth muscle contraction induced by histamine in vitro. These results provide evidence that potassium channel openers may be a new group of inhibitors of histamine release and indicate that the mechanism of its anti-anaphylactic action may be related to its potassium channel opening effect. As a result of this effect, Ca2+ influx to the mast cells decreases and Ca2+ release from calcium storage was inhibited, thus inhibiting histamine release.
本文对钾通道开放剂的抗过敏作用进行了研究并报道。结果显示，米诺地尔（Min）可抑制大鼠被动皮肤过敏反应。发现二氮嗪（Dia）和米诺地尔可在体外抑制抗原诱导的豚鼠回肠平滑肌收缩。米诺地尔可拮抗5-羟色胺诱导的大鼠皮肤毛细血管通透性增加。已证实二氮嗪可抑制A23187和48/80化合物诱导的大鼠腹腔肥大细胞组胺释放，但它不能在体外拮抗组胺诱导的豚鼠回肠平滑肌收缩。这些结果证明钾通道开放剂可能是一组新的组胺释放抑制剂，并表明其抗过敏作用机制可能与其钾通道开放效应有关。由于这种效应，肥大细胞内Ca2+内流减少，钙储存中Ca2+释放受到抑制，从而抑制组胺释放。
