Zhao Z J, Ma T X
Zhongguo Yao Li Xue Bao. 1989 Jan;10(1):78-81.
In this paper, the mechanism of the penicillin G anaphylactic reaction was studied. Rats were sensitized to penicilloyl (BPO)-protein. The incidences of anaphylactic reaction and death were 100 and 40%, respectively. After being challenged, the degranulation rates of rat cranial periosteous and peritoneal mast cells were 91 +/- 5 and 44 +/- 10%, respectively. In the control group, they were 11 +/- 5 and 7 +/- 2%, respectively. The histamine release rates from sensitized and control rat peritoneal mast cells were 13 +/- 2 and 3.0 +/- 0.4%, respectively. The passive cutaneous anaphylaxis (PCA) test demonstrated that the antibody titers in sensitized serum were 16-32.
本文研究了青霉素G过敏反应的机制。将大鼠用青霉噻唑酰基（BPO）-蛋白致敏。过敏反应和死亡的发生率分别为100%和40%。激发后，大鼠颅骨骨膜和腹膜肥大细胞的脱颗粒率分别为91±5%和44±10%。在对照组中，它们分别为11±5%和7±2%。致敏和对照大鼠腹膜肥大细胞的组胺释放率分别为13±2%和3.0±0.4%。被动皮肤过敏反应（PCA）试验表明，致敏血清中的抗体效价为16 - 32。
