Pugh C W, Gleadle J, Maxwell P H
Henry Wellcome Building of Genomic Medicine, University of Oxford, Headington, Oxford, UK.
Breast Cancer Res. 2001;3(5):313-7. doi: 10.1186/bcr313. Epub 2001 Jul 16.
Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.
缺氧诱导因子-1(HIF)在生理氧稳态中起核心作用,在大多数肿瘤中也被激活。HIF的激活可通过遗传机制发生,也可由肿瘤微环境中的缺氧导致。在某些情况下,HIF激活似乎与增殖刺激本身密切相关。HIF影响基因表达模式和肿瘤生长,尽管具体影响因肿瘤类型而异。如果应用得当,调节HIF活性可能对肿瘤治疗有益。