戊型肝炎重组疫苗

Recombinant vaccines for hepatitis E.

作者信息

Emerson S U, Purcell R H

机构信息

Molecular Hepatitis and Hepatitis Viruses Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Trends Mol Med. 2001 Oct;7(10):462-6. doi: 10.1016/s1471-4914(01)02106-2.

DOI:10.1016/s1471-4914(01)02106-2

PMID:11597521

Abstract

Hepatitis E virus causes epidemics of acute hepatitis in many developing countries. It infrequently causes disease in developed countries, but avirulent strains might circulate. Some evidence suggests that hepatitis E might be a zoonosis. There is probably only a single serotype. A candidate vaccine consisting of baculovirus-expressed recombinant capsid protein protected macaques from hepatitis E--it passed phase I clinical trials and is currently scheduled for phase II/III clinical trials.

摘要

戊型肝炎病毒在许多发展中国家引发急性肝炎流行。在发达国家，该病毒很少引发疾病，但可能存在无毒力毒株在传播。一些证据表明，戊型肝炎可能是人畜共患病。可能只有单一血清型。一种由杆状病毒表达的重组衣壳蛋白组成的候选疫苗使猕猴免受戊型肝炎感染——它已通过一期临床试验，目前计划进行二期/三期临床试验。