戊型肝炎病毒的遗传进化。

Genetic Evolution of Hepatitis E Virus.

机构信息

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

出版信息

Adv Exp Med Biol. 2023;1417:59-72. doi: 10.1007/978-981-99-1304-6_5.

DOI:10.1007/978-981-99-1304-6_5

PMID:37223859

Abstract

Comparative analysis of the genomic sequences of multiple hepatitis E virus (HEV) isolates has revealed extensive genomic diversity among them. Recently, a variety of genetically distinct HEV variants have also been isolated and identified from large numbers of animal species, including birds, rabbits, rats, ferrets, bats, cutthroat trout, and camels, among others. Furthermore, it has been reported that recombination in HEV genomes takes place in animals and in human patients. Also, chronic HEV infection in immunocompromised individuals has revealed the presence of viral strains carrying insertions from human genes. This paper reviews current knowledge on the genomic variability and evolution of HEV.

摘要

对多个戊型肝炎病毒（HEV）分离株的基因组序列进行比较分析显示，它们之间存在广泛的基因组多样性。最近，从包括鸟类、兔子、老鼠、雪貂、蝙蝠、大口黑鲈和骆驼等在内的大量动物物种中也分离和鉴定出了多种遗传上不同的 HEV 变体。此外，据报道，HEV 基因组中的重组发生在动物和人类患者中。此外，免疫功能低下个体的慢性 HEV 感染表明存在携带人类基因插入的病毒株。本文综述了目前关于 HEV 基因组变异性和进化的知识。