Emin Erdal M, Herken H, Yilmaz M, Bayazit Y A
Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):193-6. doi: 10.1016/s0169-328x(01)00219-4.
The objective was to assess the significance of the catechol-o-methyltransferase (COMT) enzyme polymorphism in migraine. For this reason, 62 migraineurs and 64 healthy volunteers were included in the study. The analysis of COMT polymorphism was performed using PCR. The H/H genotype was more frequent in the control group than in the patients group (P=0.032). The homozygous or heterozygous L allele was over represented in the migraineurs compared with the controls (P=0.013). The L/L genotype was over represented in the migraineurs who also had a family history of migraine (P=0.003). There was no relationship between aura and COMT genotypes. In conclusion, the COMT polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol drugs in migraineurs. Although altered catecholamine activity due to polymorphism of COMT gene may be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura.
目的是评估儿茶酚 - O - 甲基转移酶（COMT）酶多态性在偏头痛中的意义。因此，本研究纳入了62名偏头痛患者和64名健康志愿者。使用聚合酶链反应（PCR）对COMT多态性进行分析。对照组中H/H基因型比患者组更常见（P = 0.032）。与对照组相比，偏头痛患者中纯合或杂合L等位基因的比例过高（P = 0.013）。在有偏头痛家族史的偏头痛患者中，L/L基因型比例过高（P = 0.003）。先兆与COMT基因型之间没有关系。总之，COMT多态性可能在偏头痛患者儿茶酚类药物代谢的个体差异方面具有潜在的药理学重要性。尽管由于COMT基因多态性导致的儿茶酚胺活性改变可能是偏头痛发病机制中的机制之一，但这些机制与先兆的有无无关。
