Schoepe H, Pache C, Neubauer A, Potschka H, Schlapp T, Wieler L H, Baljer G
Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, D-35392 Giessen, Germany.
Infect Immun. 2001 Nov;69(11):7194-6. doi: 10.1128/IAI.69.11.7194-7196.2001.
Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capable of significantly reducing activities induced by wild-type toxin. Thus, rAT121/91 could be a useful vaccine candidate.
产气荚膜梭菌突变株121A/91既无酶活性（磷脂酶C）也无溶血活性。然而，cpa基因和相应的α毒素变体是可检测到的。用这种基因构建的α毒素变体rAT121/91进行疫苗接种可诱导产生能够显著降低野生型毒素诱导活性的抗体。因此，rAT121/91可能是一种有用的候选疫苗。
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