Romas N A, Ionascu L, Sholem S, Ionescu G, Veenema R J
J Urol. 1975 Aug;114(2):223-5. doi: 10.1016/s0022-5347(17)66991-x.
Abnormal tryptophan metabolism in patients with bladder carcinoma has been reported to have an extremely high correlation with future tumor recurrences. The methods for determination of these urinary metabolites have not been applicable for routine clinical use in the past. A new method is described using thin layer chromatography followed by fluorescent scanning with the SD 3000 spectrodensitometer. The range of recovery for the 6 tryptophan metabolites was from 96.9 to 106.7 per cent. In our study 31 per cent of the male and 50 per cent of the female bladder cancer patients had 2 or more abnormal tryptophan metabolites.
据报道，膀胱癌患者色氨酸代谢异常与未来肿瘤复发具有极高的相关性。过去，测定这些尿液代谢物的方法并不适用于常规临床应用。本文描述了一种新方法，即采用薄层色谱法，随后用SD 3000分光密度计进行荧光扫描。6种色氨酸代谢物的回收率在96.9%至106.7%之间。在我们的研究中，31%的男性和50%的女性膀胱癌患者有2种或更多异常的色氨酸代谢物。
