多囊卵巢综合征患者的子宫灌注与激素模式
Uterine perfusion and hormonal pattern in patients with polycystic ovary syndrome.
作者信息
Ajossa S, Guerriero S, Paoletti A M, Orrù M, Floris S, Mannias M, Melis G B
机构信息
Department of Obstetrics and Gynecology, University of Cagliari, Ospedale San Giovanni di Dio, Via Ospedale 46, 09124, Cagliari, Italy.
出版信息
J Assist Reprod Genet. 2001 Aug;18(8):436-40. doi: 10.1023/a:1016686721307.
PURPOSE
To evaluate whether polycystic ovary syndrome (PCOS) patients with different pulsatility index (PI) of uterine artery showed differences in their hormonal pattern.
METHODS
Eighty-eight PCOS-affected patients and 15 controls were submitted to Doppler flow measurement of uterine artery; LH, FSH PRL, estradiol, and androgens concentration determination; and BMI evaluation during early follicular phase.
RESULTS
The mean PI of uterine artery of PCOS patients was significantly higher than control group (2.97 +/- 0.9 vs. 1.89 +/- 0.2 respectively). The distribution of the PI'values was significantly different in the PCOS-affected patients and in control group. The plasma levels of DHEAS and BMI were significantly higher in PCOS patients with PI > or = 3 than in PCOS patients with PI < 3.
CONCLUSION
High resistance in the uterine artery is present in PCOS patients, but a wide range PI values of uterine artery is present. BMI and DHEAS seem to be factors interfering with uterine perfusion.
目的
评估子宫动脉搏动指数（PI）不同的多囊卵巢综合征（PCOS）患者其激素模式是否存在差异。
方法
88例PCOS患者和15例对照者接受子宫动脉多普勒血流测量；测定卵泡早期的促黄体生成素（LH）、促卵泡生成素（FSH）、泌乳素（PRL）、雌二醇和雄激素浓度；并评估体重指数（BMI）。
结果
PCOS患者子宫动脉的平均PI显著高于对照组（分别为2.97±0.9和1.89±0.2）。PCOS患者和对照组PI值的分布有显著差异。PI≥3的PCOS患者的硫酸脱氢表雄酮（DHEAS）血浆水平和BMI显著高于PI<3的PCOS患者。
结论
PCOS患者子宫动脉存在高阻力，但子宫动脉PI值范围较宽。BMI和DHEAS似乎是影响子宫灌注的因素。
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