通过细胞表面钙网蛋白激活人单核细胞系U937
Activation of human monocyte cell line U937 via cell surface calreticulin.
作者信息
Cho J H, Homma K J, Kanegasaki S, Natori S
机构信息
Natori Special Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
出版信息
Cell Stress Chaperones. 2001 Apr;6(2):148-52. doi: 10.1379/1466-1268(2001)006<0148:aohmcl>2.0.co;2.
Abstract
U937 cells were found to be activated by an antibacterial peptide, KLKLLLLLKLK-NH2 (L5), to generate superoxide anion (O2-)-like peripheral neutrophils. However, the state of cell surface calreticulin, a possible receptor for L5, was suggested to differ between neutrophils and U937 cells. Unlike the former, the latter ones were activated by anti-C-domain peptide antibody of calreticulin even in the absence of L5 and generated O2- in a GTP-binding protein (G-protein)-dependent manner.
摘要
研究发现，抗菌肽KLKLLLLLKLK-NH2（L5）可激活U937细胞，使其产生类似外周血中性粒细胞的超氧阴离子（O2-）。然而，细胞表面钙网蛋白作为L5可能的受体，其状态在中性粒细胞和U937细胞之间可能存在差异。与中性粒细胞不同，即使在没有L5的情况下，U937细胞也会被钙网蛋白的抗C结构域肽抗体激活，并以一种依赖于GTP结合蛋白（G蛋白）的方式产生O2-。
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