Stehbens W E, Hill R W, Fitzjohn T P, Sharma A K
Department of Pathology and Molecular Medicine, Wellington School of Medicine, PO Box 7343, Wellington South, New Zealand.
Cardiovasc Pathol. 2001 Jul-Aug;10(4):197-203. doi: 10.1016/s1054-8807(01)00075-8.
A 41-year-old man with a small perimembranous ventricular septal defect (VSD) developed aneurysms and aortic elongation, tortuosity and dissecting aneurysm. The asymptomatic VSD, without pulmonary circulatory disturbance, was considered hemodynamically benign and too small to warrant surgical closure. However, prolonged strenuous sporting activities could have potentiated premature development of aortic sclerosis and the unusual vascular lesions secondary to the VSD, and an injury may have precipitated mural dissection in the vulnerable aortic wall. Clinicopathological analysis of the unusual complications associated with the VSD suggests that closure of the defect at an early age should be considered to possibly obviate premature degenerative, valvular and vascular changes in adulthood and also secondary endocardial infection.
一名患有小型膜周部室间隔缺损（VSD）的41岁男性出现了动脉瘤以及主动脉伸长、迂曲和夹层动脉瘤。该无症状的室间隔缺损无肺循环障碍，从血流动力学角度被认为是良性的，且过小无需手术闭合。然而，长期剧烈的体育活动可能会加速主动脉硬化以及室间隔缺损继发的异常血管病变的过早发展，并且一次损伤可能在脆弱的主动脉壁上引发壁间夹层。对与室间隔缺损相关的异常并发症的临床病理分析表明，应考虑在幼年时期闭合缺损，以可能避免成年期过早出现退行性、瓣膜和血管变化以及继发性心内膜感染。
