Khaitov R M, Leskov V P
State Research Centre-Institute of Immunology, RF Ministry of Health, Russia, 115478, Moscow, Kashirskoe Shosse, 24, Korp. 2.
Ross Fiziol Zh Im I M Sechenova. 2001 Aug;87(8):1060-72.
Changes occurring in stress response in the immune system and their effect upon resistance against infectious diseases, were studied. The main mechanisms of the stress induction involve: enhancement of the corticotropin-releasing factor and/or adrenocorticotropic hormone synthesis under the effect of interleukin-1; induced by an infection synthesis of the adrenocorticotropic hormone by lymphocytes, enhancement of the corticotropin-releasing factor synthesis under the effect of a psycho-emotional tension. The main reasons of decline in the immune-competence in stress, are discussed. Significance of stress-response as one of the mechanisms of the organism physiological response to extreme circumstances, is considered.
研究了免疫系统应激反应中发生的变化及其对抵抗传染病能力的影响。应激诱导的主要机制包括：在白细胞介素 -1 的作用下促肾上腺皮质激素释放因子和 / 或促肾上腺皮质激素合成增强；由感染诱导淋巴细胞合成促肾上腺皮质激素，在心理 - 情绪紧张的作用下促肾上腺皮质激素释放因子合成增强。讨论了应激状态下免疫能力下降的主要原因。考虑了应激反应作为机体对极端情况的生理反应机制之一的意义。
