Natochin Iu V, Prutskova N P, Shakhmatova E I
M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., Russia, 194223, St. Petersburg, Thorez Av., 44, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Aug;87(8):1095-105.
The experiments carried out on the urinary bladder of the frog Rana temporaria L. have shown that the period of recovery of water impermeability after an increase of osmotic water permeability induced by arginine-vasotocin, desmopressin, or cAMP depends on the degree of increase of the osmotic permeability but not on the nature of the substance stimulating the increase of osmotic water permeability. The removal of the hormone in the absence of autacoids fails to recover the water impermeability. After cessation of the vasotocin action the water permeability decrease is delayed if phospholipase A2 and cyclooxygenase are inhibited by qiunacrine and voltaren, respectively. An agonist of V1-receptors has no effect on dynamics of the recovery of water impermeability. This recovery has been shown to depend on PGE2 concentration in the serosal solution after the hormone removal. The obtained results indicate that decrease of water permeability depends not only on removal of vasotocin or cAMP but also on involvement of autacoids.
在泽蛙（Rana temporaria L.）膀胱上进行的实验表明，精氨酸血管加压素、去氨加压素或环磷酸腺苷诱导渗透水通透性增加后，水不透性的恢复时间取决于渗透通透性的增加程度，而不取决于刺激渗透水通透性增加的物质的性质。在没有自分泌物质的情况下去除激素并不能恢复水不透性。血管加压素作用停止后，如果分别用喹那克林和扶他林抑制磷脂酶A2和环氧化酶，水通透性的降低会延迟。V1受体激动剂对水不透性恢复动力学没有影响。研究表明，这种恢复取决于激素去除后浆膜溶液中前列腺素E2的浓度。所得结果表明，水通透性的降低不仅取决于血管加压素或环磷酸腺苷的去除，还取决于自分泌物质的参与。
