结节性淋巴细胞为主型霍奇金淋巴瘤的临床病理研究
[A clinicopathological study of nodular lymphocyte predominance Hodgkin's disease].
作者信息
Deng F, Liu X, Tang W
机构信息
Department of Pathology, Zunyi Medical College, Zunyi 563003.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 1999 May;20(5):239-41.
OBJECTIVE
To investigate the clinicopathological characteristics of nodular lymphocyte predominance Hodgkin's disease.
METHODS
Eleven samples of paraffin embedded lymph node and one of frozen lymph node from nodular lymphocyte predominance Hodgkin's disease patients were studied. HE staining, immunohistochemistry for CD3, CD19, CD20, CD30, CD45RB, kappa and lambda light chain and single L&H cell polymerase chain reaction (PCR) were performed.
RESULTS
The diagnosis of nodular lymphocyte predominance Hodgkin's disease was established by the identification of characteristic L&H cells in the nodular small lymphocytes and histiocytes background. L&H cells expressed CD19(10/12), CD20(12/12), CD45RB(12/12) and kappa light chain (11/12). IgH and V kappa 4 family gene rearrangements were detected in the single L&H cell. Eight of the patients survived more than 5 years.
CONCLUSION
Nodular lymphocyte predominance Hodgkin's disease has a very slow disease course and a better prognosis. It is a malignant lymphoma derived from B cells.
目的
探讨结节性淋巴细胞为主型霍奇金淋巴瘤的临床病理特征。
方法
研究11例结节性淋巴细胞为主型霍奇金淋巴瘤患者石蜡包埋淋巴结样本及1例冰冻淋巴结样本。进行苏木精-伊红（HE）染色、CD3、CD19、CD20、CD30、CD45RB、κ和λ轻链免疫组化以及单个L&H细胞聚合酶链反应（PCR）。
结果
通过在结节性小淋巴细胞和组织细胞背景中识别特征性L&H细胞，确立了结节性淋巴细胞为主型霍奇金淋巴瘤的诊断。L&H细胞表达CD19（10/12）、CD20（12/12）、CD45RB（12/12）和κ轻链（11/12）。在单个L&H细胞中检测到IgH和Vκ4家族基因重排。8例患者存活超过5年。
结论
结节性淋巴细胞为主型霍奇金淋巴瘤病程非常缓慢，预后较好。它是一种起源于B细胞的恶性淋巴瘤。
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