[造血细胞中细胞型巨噬细胞集落刺激因子（M-CSF）和巨噬细胞集落刺激因子受体（M-CSFR）的表达]
[Expressions of cellular M-CSF and M-CSFR in hematopoietic cells].
作者信息
Zhang Q, Xue Y, Song Y
机构信息
Institute of Hematology, CAMS, PUMC, Tianjin 300020.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 1999 May;20(5):249-51.
OBJECTIVE
To study the distribution of cellular M-CSF and its receptor in abnormal hematopoiesis.
METHODS
Six hematopoietic cell lines, 144 bone marrow (BM) and 160 peripheral blood (PB) samples were investigated with ABC immunoperoxidase assay.
RESULTS
Cellular M-CSF and/or M-CSFR were positive in all the 6 hematopoietic cell lines, a few normal BM(4 cases) and PB (32 cases) samples, hematological malignancies and a few benign hematological disorder samples. M-CSF and M-CSFR were found mainly in granulocytic lineage cells, seldom in erythroid and megakaryocytic lineage cells and never in lymphocytes. M-CSF and M-CSFR usually presented in cytoplasma and membrane and in some cases in nuclei.
CONCLUSION
Cellular M-CSF and M-CSFR is widely distributed in abnormal hematopoiesis, and is especially high in myeloid leukemias.
目的
研究细胞型巨噬细胞集落刺激因子（M-CSF）及其受体在异常造血中的分布情况。
方法
采用ABC免疫过氧化物酶法对6种造血细胞系、144份骨髓（BM）样本和160份外周血（PB）样本进行研究。
结果
在所有6种造血细胞系、少数正常骨髓（4例）和外周血（32例）样本、血液系统恶性肿瘤及少数良性血液系统疾病样本中，细胞型M-CSF和/或M-CSFR呈阳性。M-CSF和M-CSFR主要见于粒细胞系细胞，很少见于红系和巨核细胞系细胞，从未见于淋巴细胞。M-CSF和M-CSFR通常存在于细胞质和细胞膜中，在某些情况下也存在于细胞核中。
结论
细胞型M-CSF和M-CSFR在异常造血中广泛分布，在髓系白血病中尤其高表达。
Zotero 插件