Shang X, Yin H, Lu A, Zhang L
Department of Pediatrics, Second Hospital, Beijing Medical University, Beijing 100044, China.
Chin Med J (Engl). 1999 Jul;112(7):620-2.
To evaluate the effect of recombinant human granulocyte colony stimulating factor (rhG-CSF) on accelerating neutrophil recovery and decrease fatal infections for childhood acute myeloid leukemia (AML).
From November 1992 to March 1997, 45 patients were enrolled into our study and 15 were newly diagnosed. All were treated with high dose chemotherapy combined with rhG-CSF.
Of 15 newly diagnosed patients, 13 achieved complete remission (CR) after one course of therapy and 2 achieved CR after two courses of therapy. For newly diagnosed patients, the durations of absolute neutrophil counts (ANC) < 0.5 x 10(9)/L were 5 days and 10 days in rhG-CSF group and control group respectively (P < 0.05). The incidences of infection of these two groups were 40% and 60% respectively (P < 0.05). As for patients who received intensive therapy, the durations of ANC < 0.5 x 10(9)/L were 5 days and 8 days in rhG-CSF group and control group, respectively (P < 0.05), and the incidences of infection were 25% and 44.4% respectively (P < 0.05).
The application of rhG-CSF in children with AML after chemotherapy may hasten the hematopoietic recovery. The duration of neutropenia was shortened by 3-4 days, and the incidence of fatal infection was reduced. rhG-CSF does not stimulate AML growth in vivo.
评估重组人粒细胞集落刺激因子（rhG-CSF）对儿童急性髓系白血病（AML）加速中性粒细胞恢复及降低致命感染发生率的作用。
1992年11月至1997年3月，45例患者纳入本研究，其中15例为新诊断患者。所有患者均接受大剂量化疗联合rhG-CSF治疗。
15例新诊断患者中，13例在一个疗程治疗后达到完全缓解（CR），2例在两个疗程治疗后达到CR。对于新诊断患者，rhG-CSF组和对照组中性粒细胞绝对计数（ANC）<0.5×10⁹/L的持续时间分别为5天和10天（P<0.05）。两组感染发生率分别为40%和60%（P<0.05）。对于接受强化治疗的患者，rhG-CSF组和对照组ANC<0.5×10⁹/L的持续时间分别为5天和8天（P<0.05），感染发生率分别为25%和44.4%（P<0.05）。
rhG-CSF应用于化疗后的AML患儿可加速造血恢复。中性粒细胞减少持续时间缩短3 - 4天，致命感染发生率降低。rhG-CSF在体内不刺激AML生长。
