芫花对未孕大鼠离体子宫条的作用
[Effect of yuanhua on isolated uterine strips in unpregnant rats].
作者信息
Ma Y, Liu H, Qu S, Qiu X, Zhang Y, Ding Y, Wei Y
机构信息
Department of Physiology, Lanzhou Medical College, Lanzhou 730000.
出版信息
Zhongguo Zhong Yao Za Zhi. 1998 Jul;23(7):429-30, inside back cover.
OBJECTIVE
To explore the mechanism on the effect of Yuanhua on the contractile activity of isolated uterine strips in rats under artificial oestrum.
METHOD
Isolated strips were suspended in a tissue chamber in which Yuanhua was added with some antagonists of inhibitors or without.
RESULT
Yuanhua could excite the uterine smooth muscle strips in a dose-dependent manner, but atropine, phentolamine, hexamethonium and diphenhydramine could not inhibit this exciting action. This exciting effect could be inhibited completely by verapamil and decreased by indomethacin(inhibitor of prostaglandin synthase).
CONCLUSION
The exciting effect of Yuanhua on un-pregnant rats in vitro might be related to an action on the cell membrane Ca2+ channel as well as to a partial stimulation of synthesis and release of PG.
目的
探讨芫花对人工动情期大鼠离体子宫条收缩活动影响的机制。
方法
将离体子宫条悬挂于组织浴槽中，分别加入芫花及一些抑制剂拮抗剂或不加。
结果
芫花可剂量依赖性地兴奋子宫平滑肌条，但阿托品、酚妥拉明、六甲铵和苯海拉明不能抑制这种兴奋作用。维拉帕米可完全抑制这种兴奋效应，吲哚美辛（前列腺素合成酶抑制剂）可使其减弱。
结论
芫花对未孕大鼠子宫体外兴奋作用可能与作用于细胞膜Ca2+通道及部分刺激前列腺素合成与释放有关。
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