[磷脂酶C负向调节A-431细胞中表皮生长因子受体的酪氨酸磷酸化]
[Phospholipase C negatively regulates tyrosine phosphorylation of EGF receptor in A-431 cells].
作者信息
Evdonin A L, Leonov A N, Tsupkina N V, Medvedeva N D
机构信息
Institute of Cytology RAS, St. Petersburg.
出版信息
Tsitologiia. 2001;43(8):797-802.
It is known that EGF induces tyrosine phosphorylation and internalization of the EGF receptor in A-431 cells. U73122, an inhibitor of phospholipase C, induces tyrosine phosphorylation of the EGF receptor and its association with phospholipase C still in nonstimulated cells. In U73122 treated cells EGF exerted no effect on these processes. Receptor-mediated endocytosis was not observed in A-431 cells treated with U73122. The reorganization of actin cytoskeleton was detected in U73122 cells.
已知表皮生长因子（EGF）可诱导A - 431细胞中表皮生长因子受体的酪氨酸磷酸化和内化。U73122是一种磷脂酶C抑制剂，在未受刺激的细胞中也可诱导表皮生长因子受体的酪氨酸磷酸化及其与磷脂酶C的结合。在用U73122处理的细胞中，表皮生长因子对这些过程没有影响。在用U73122处理的A - 431细胞中未观察到受体介导的内吞作用。在U73122处理的细胞中检测到肌动蛋白细胞骨架的重组。
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