Takeuchi S
Jpn Heart J. 1975 May;16(3):280-92. doi: 10.1536/ihj.16.280.
Hemodynamic effects of dopamine were studied on 30 open-chest dogs with experimental myocardial infarction. These dogs were divided into 3 groups. Three different doses of intravenous dopamine, 5, 10, and 20 mug/Kg/min, were administered for 30 min. Heart rate and myocardial contractility were increased dose-dependently. Total peripheral vascular resistance was reduced with 5 or 10 mug/Kg/min of dopamine. With 20 mug/Kg/min of dopamine, it became the lowest 5 min after the initiation of infusion but increased above the control value 20 min after the start of administration. Renal vascular resistance was decreased with 5 mug/Kg/min of dopamine but increased with 20 mug/Kg/min. These results suggested that this drug would be useful for treatment of shock state.
研究了多巴胺对30只开胸实验性心肌梗死犬的血流动力学影响。这些犬被分为3组。静脉注射三种不同剂量的多巴胺，分别为5、10和20微克/千克/分钟，持续30分钟。心率和心肌收缩力呈剂量依赖性增加。多巴胺剂量为5或10微克/千克/分钟时，总外周血管阻力降低。多巴胺剂量为20微克/千克/分钟时，输注开始后5分钟降至最低，但给药开始后20分钟升高至对照值以上。多巴胺剂量为5微克/千克/分钟时肾血管阻力降低，但剂量为20微克/千克/分钟时肾血管阻力增加。这些结果表明，该药对休克状态的治疗可能有用。
