Lesesve J F, Salignac S, Lecompte T
Service d'hématologie biologique, CHU Nancy, 54511 VandOEuvre-lès-Nancy, France.
Ann Biol Clin (Paris). 2001 Sep-Oct;59(5):551-8.
Schistocytes result from red cell fragmentation. The identification of the schistocytes is critical for decisions on appropriate management of the patients. Detection of schistocytes on a peripheral blood smear is an abnormal finding, which raises the occurrence of a microangiopathy. The avaibility of effective treatment prompted the urgency to establish this crucial diagnosis. Nevertheless, schistocytes can be observed in a broader spectrum of disorders than thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, or might be delayed even absent.
裂红细胞由红细胞破碎产生。裂红细胞的识别对于患者的恰当管理决策至关重要。在外周血涂片上检测到裂红细胞是一项异常发现,提示微血管病的发生。有效治疗方法的可获得性促使了做出这一关键诊断的紧迫性。然而,裂红细胞可见于比血栓性血小板减少性紫癜/溶血尿毒综合征更广泛的一系列疾病中,或者可能延迟出现甚至缺如。