Carvalho T L, Mota-Santos T, Cumano A, Demengeot J, Vieira P
Instituto Gulbenkian de Ciência, 2781 Oeiras, Portugal.
J Exp Med. 2001 Oct 15;194(8):1141-50. doi: 10.1084/jem.194.8.1141.
Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum immunoglobulins is increased three- to fivefold. Both the MZ phenotype and the increase in serum IgM are T cell independent. These findings reveal a previously undescribed pathway of B lymphopoiesis that is active in early life and is interleukin 7 independent. This pathway generates B1 cells and a normal sized MZ B lymphocyte compartment.
白细胞介素7是小鼠T和B淋巴细胞发育的关键因素。我们现在报告，在缺乏白细胞介素7的情况下，B淋巴细胞的产生仅发生在胎儿期和围生期，7周龄后停止。然而，在外周器官中，B淋巴细胞库在成年期保持稳定，仅由属于B1和边缘区（MZ）区室的细胞组成。这伴随着分泌免疫球蛋白（Ig）M和IgG的细胞频率增加50倍，血清免疫球蛋白浓度增加三至五倍。MZ表型和血清IgM的增加均不依赖于T细胞。这些发现揭示了一种以前未描述的B淋巴细胞生成途径，该途径在生命早期活跃且不依赖于白细胞介素7。该途径产生B1细胞和正常大小的MZ B淋巴细胞区室。
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