B-1细胞的发育与功能。

Development and function of B-1 cells.

作者信息

Hayakawa K, Hardy R R

机构信息

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

出版信息

Curr Opin Immunol. 2000 Jun;12(3):346-53. doi: 10.1016/s0952-7915(00)00098-4.

DOI:10.1016/s0952-7915(00)00098-4

PMID:10858035

Abstract

Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely interpreted in recent years as supporting a simple 'activation' model for the origin of CD5+/B-1 B cells. However cell transfer experiments over 10 years ago and recent work investigating pre-BCR signaling suggest striking differences between B cell development in fetal liver and adult bone marrow, lending support for a 'lineage' model that we favor. Recent progress has been made relating to the development and function of the CD5+/B-1 B cell subpopulation in mice; the data can be viewed in the context of the generation of this subpopulation by a distinctive fetal B cell developmental process.

摘要

近年来，免疫球蛋白转基因小鼠和BCR突变小鼠的实验结果被广泛解读为支持CD5⁺/B-1 B细胞起源的简单“激活”模型。然而，10多年前的细胞移植实验以及最近对前B细胞受体信号传导的研究表明，胎肝和成年骨髓中B细胞发育存在显著差异，这支持了我们所倾向的“谱系”模型。在小鼠CD5⁺/B-1 B细胞亚群的发育和功能方面已取得了最新进展；这些数据可以在通过独特的胎儿B细胞发育过程产生该亚群的背景下进行审视。