Tohda S, Murakami N, Nara N
Department of Laboratory Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan.
Int J Mol Med. 2001 Nov;8(5):549-51.
Multicentric Castleman's disease (MCD) is a lymphoproliferative disorder characterized by systemic lymphadenopathy and hypergammaglobulinemia. Recently, a French group reported that human herpesvirus 8 (HHV8) DNA was detected in tissue samples of MCD patients. The detection rate was especially high in human immunodeficiency virus (HIV)-positive MCD patients. Thus, HHV8 infection seems to be closely related to HIV infection. In Japan, the HIV infection rate in the general population is very low. To examine whether HHV8 is actually related to MCD in Japan, we performed nested polymerase chain reaction for the HHV8 genome using DNA samples from 7 patients with MCD and 23 patients with related diseases such as POEMS syndrome, amyloidosis, myeloma and lymphoma. They were all HIV-negative Japanese. Three of 7 MCD patients were positive for HHV8. There were no clear differences in clinical characteristics between HHV8-positive patients and negative ones. All other patients were negative for HHV8. Thus, we have shown that some MCD patients in Japan are also infected with HHV8.
多中心性Castleman病（MCD）是一种以系统性淋巴结病和高球蛋白血症为特征的淋巴增生性疾病。最近，一个法国研究小组报告称，在MCD患者的组织样本中检测到了人类疱疹病毒8型（HHV8）DNA。在人类免疫缺陷病毒（HIV）阳性的MCD患者中，检测率尤其高。因此，HHV8感染似乎与HIV感染密切相关。在日本，普通人群中的HIV感染率非常低。为了研究在日本HHV8是否真的与MCD有关，我们使用来自7例MCD患者和23例患有相关疾病（如POEMS综合征、淀粉样变性、骨髓瘤和淋巴瘤）患者的DNA样本，对HHV8基因组进行了巢式聚合酶链反应。他们都是HIV阴性的日本人。7例MCD患者中有3例HHV8呈阳性。HHV8阳性患者和阴性患者的临床特征没有明显差异。所有其他患者的HHV8均为阴性。因此，我们已经证明日本的一些MCD患者也感染了HHV8。
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