与非梗阻性结肠癌相比，结肠和直肠癌的梗阻性癌体积较小。

Obstructing carcinomas of the colon and rectum have a smaller size compared with those of non-obstructing carcinomas.

作者信息

Nozoe T, Yasuda M, Honda M, Inutsuka S, Korenaga D

机构信息

Department of General Surgery, Fukuoka Dental College Hospital, Sawara Ward, Fukuoka 814-0193, Japan.

出版信息

Oncol Rep. 2001 Nov-Dec;8(6):1313-5. doi: 10.3892/or.8.6.1313.

DOI:10.3892/or.8.6.1313

PMID:11605056

Abstract

The aim of the current study was to elucidate the histopathological characteristics of obstructing carcinoma of the colon and rectum. We studied 72 patients with colorectal carcinoma, including 13 with obstructing carcinoma. The obstruction carcinomas occurred in sigmoid colon significantly more frequently than did non-obstructing carcinomas (p=0.007). The mean size of the obstructing carcinomas was 3.7+/-0.9 cm, which was significantly smaller than that of non-obstructing carcinomas (5.4+/-1.9 cm, p=0.003). The proportion of lymph node metastasis in obstructing carcinomas was 66.9%, which was significantly higher than that in non-obstructing carcinomas (42.4%, p=0.021). The proportion of carcinomas classified into Dukes' C or D in obstructing carcinomas was 84.6% and was significantly higher than that in non-obstructing carcinomas (52.5%, p=0.026). The pathogenesis of obstruction in colorectal carcinoma can be also derived from the contraction of the intestinal lumen caused by the condensation of cancer cells.

摘要

本研究的目的是阐明结肠和直肠癌性梗阻的组织病理学特征。我们研究了72例结直肠癌患者，其中13例为癌性梗阻患者。与非梗阻性癌相比，梗阻性癌在乙状结肠的发生率显著更高（p = 0.007）。梗阻性癌的平均大小为3.7±0.9 cm，明显小于非梗阻性癌（5.4±1.9 cm，p = 0.003）。梗阻性癌的淋巴结转移比例为66.9%，显著高于非梗阻性癌（42.4%，p = 0.021）。梗阻性癌中分类为Dukes' C或D期的癌的比例为84.6%，显著高于非梗阻性癌（52.5%，p = 0.026）。结直肠癌梗阻的发病机制也可能源于癌细胞凝聚导致的肠腔收缩。