Volonté M A, Perani D, Lanzi R, Poggi A, Anchisi D, Balini A, Comi G, Fazio F
Movement Disorder Unit, Department of Neuroscience, Istituto Scientifico Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, Italy.
J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):691-5. doi: 10.1136/jnnp.71.5.691.
A [(18)F]-FDG PET study was performed in a 44 year old man with proximal kinesigenic choreoathetosis (PKC) secondary to idiopathic primary hypoparathyroidism (IPH) before and 1 year after calcium/calcitriol therapy. The [(18)F]-FDG PET performed before the start of the therapy disclosed a significant bilateral hypometabolism in the ventral striatum. One year later, with the patient still under calcium/calcitriol therapy and free of any occurrence of PKC episodes, the [(18)F]-FDG PET did not show the previously detected hypometabolism. The hypometabolism of the ventral striatum secondary to hypocalcaemia seems to play a crucial part in the pathogenesis of paroxysmal kinesigenic choreoathetosis associated with IPH.
对一名44岁患有继发于特发性原发性甲状旁腺功能减退症（IPH）的近端运动诱发性舞蹈手足徐动症（PKC）的男性患者，在钙/骨化三醇治疗前及治疗1年后进行了一项[（18）F]-FDG PET研究。治疗开始前进行的[（18）F]-FDG PET显示腹侧纹状体存在明显的双侧代谢减低。一年后，患者仍在接受钙/骨化三醇治疗且未出现任何PKC发作，[（18）F]-FDG PET未显示先前检测到的代谢减低。低钙血症继发的腹侧纹状体代谢减低似乎在与IPH相关的阵发性运动诱发性舞蹈手足徐动症的发病机制中起关键作用。
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