Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion.

作者信息

Amrolia P J, Rao K, Slater O, Ramsay A, Veys P A, Webb D K

机构信息

Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK.

出版信息

Bone Marrow Transplant. 2001 Sep;28(6):623-5. doi: 10.1038/sj.bmt.1703195.

We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.