Lev-Ran A
Obstet Gynecol. 1975 Sep;46(3):313-6.
Twelve women with congenital adrenal hyperplasia are reported. Initial diagnoses were made at ages ranging from 12 to 32, with epiphyseal fusion complete in all patients. During 6 to 10 years of corticosteroid therapy there occurred substantial reduction of hypertrichosis, disappearance of temporal recession, and decrease in eroticism. In 11 patients menstrual bleeding occurred within 4 months. Urinary excretion of total gonadotropins remained unchanged; total estrogens decreased slightly. By the end of followup, 7 patients with a mean age of 17 years had regular menses, 6 were ovulating, and 1 had a pregnancy. The other 5 patients, who continued to have irregular, anovulatory menstrual cycles, had a mean age of 28 years. The findings suggest that when excessive androgenization continues for a considerable period of time after puberty (as judged by bone age) noncyclic functioning of the gonadotropic mechanism is rendered irreversible.
报告了12例先天性肾上腺皮质增生症女性患者。初次诊断年龄在12岁至32岁之间，所有患者骨骺均已完全融合。在接受6至10年的皮质类固醇治疗期间，多毛症明显减轻，颞部凹陷消失，性欲减退。11例患者在4个月内出现月经出血。促性腺激素总排泄量保持不变；总雌激素略有下降。随访结束时，7例平均年龄为17岁的患者月经规律，6例排卵，1例怀孕。另外5例患者月经周期持续不规律、无排卵，平均年龄为28岁。研究结果表明，青春期后（根据骨龄判断）雄激素化持续相当长一段时间时，促性腺机制的非周期性功能会变得不可逆。
