Song Z, Chen X
Zhonghua Yi Shi Za Zhi. 1996;26(1):33-8.
This paper gives a general introduction to the studies on the formulation and invention of anti-tumor remedies from 1950s-1980s. Beginning from 50s, antitumor antibiotics were investigated. New alkylicompoun and antibiotics were found in the 60s, while more new natural compounds were found in the 70s. Researches were proceeded in the 80s based on the former achievements. Through the process of about 30 years, nearly 80 new species were produced, many anti-tumor pharmaceutical corporations established, and a contigent of high level research workers was formed. However, there still exist a rather large gap between the urgent clinical needs for clinical chemotherapeutics and the actual status. Based on some 30 years of experience in China, the following points were summarized, i.e., shifting from merely imitation to invention, developing the spirit of massive cooperation, investigating the thesaurus of TCM, developing China's plant resources, and traditional Chinese preventive idea, so that the stress point for research be laid on the invention of preventive anti-tumor remedies.
本文对20世纪50年代至80年代抗肿瘤药物的研制与发明研究作了全面介绍。从50年代开始,人们对抗肿瘤抗生素展开研究。60年代发现了新的烷基化合物和抗生素,70年代则发现了更多新的天然化合物。80年代在前人成果的基础上继续开展研究。经过约30年的历程,产生了近80个新物种,成立了许多抗肿瘤制药公司,形成了一批高水平的研究人员。然而,临床化疗药物的迫切临床需求与实际状况之间仍存在相当大的差距。基于中国约30年的经验,总结了以下几点,即从单纯模仿转向发明创造,发扬大规模合作精神,研究中医词库,开发中国的植物资源以及传统中医预防理念,以便将研究重点放在预防性抗肿瘤药物的发明上。