采用邻对滴滴滴（o,p'-DDD）与氨鲁米特联合治疗肾上腺皮质癌。
Treatment of an adrenal cortical carcinoma with a combination of o,p'-DDD and aminoglutethimide.
作者信息
Scott R D
出版信息
Postgrad Med J. 1975 Jan;51(591):35-7. doi: 10.1136/pgmj.51.591.35.
Abstract
A patient with Cushing's syndrome due to an adrenocortical carcinoma is described. Treatment of residual disease and functional metastases was attempted with o,p′-DDD and later aminoglutethimide. Aminoglutethimide in a daily dose of 1 g appeared to have little effect additional to o,p′-DDD. It is important to maintain replacement therapy with cortico-steroids throughout the use of these drugs.
摘要
本文描述了一名因肾上腺皮质癌导致库欣综合征的患者。尝试使用邻对滴滴滴（o,p′-DDD）以及后来的氨鲁米特治疗残留疾病和功能性转移灶。每日剂量为1克的氨鲁米特似乎在邻对滴滴滴之外几乎没有额外效果。在整个使用这些药物的过程中，持续使用皮质类固醇进行替代治疗很重要。
相似文献
1
Treatment of an adrenal cortical carcinoma with a combination of o,p'-DDD and aminoglutethimide.采用邻对滴滴滴（o,p'-DDD）与氨鲁米特联合治疗肾上腺皮质癌。
Postgrad Med J. 1975 Jan;51(591):35-7. doi: 10.1136/pgmj.51.591.35.
2
[The effects of o,p'-DDD on human adrenal steroid synthesis].[邻对二氯二苯二氯乙烷对人体肾上腺类固醇合成的影响]
Nihon Naibunpi Gakkai Zasshi. 1984 Jul 20;60(7):852-71. doi: 10.1507/endocrine1927.60.7_852.
3
Current therapeutic concepts--Cushing's syndrome.
J Am Pharm Assoc. 1975 May;15(5):261-70.
4
Significant regression of the tumor combined with the high level of plasma cortisol by low-dose administration of O, p'-DDD in a case with Cushing's syndrome caused by adrenocortical carcinoma.
Tohoku J Exp Med. 1986 Dec;150(4):407-15. doi: 10.1620/tjem.150.407.
5
[Cushing's syndrome. Medical treatment of adrenal hypercorticism].[库欣综合征。肾上腺皮质功能亢进的医学治疗]
Horm Res. 1980;13(4-5):317-24. doi: 10.1159/000179298.
6
Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.伴有库欣综合征和假性甲状旁腺功能亢进的女性化肾上腺皮质癌
Arch Intern Med. 1978 Feb;138(2):301-3.
7
[Use of mitotane (o,p'-DDD) in adrenal cortex hyperfunction].
Endokrynol Pol. 1982;33(1-3):99-104.
8
[Treatment of glycoactive hypercorticism].
Clin Ter. 1984 Nov 30;111(4):367-72.
9
Adrenal carcinoma.肾上腺皮质癌
Curr Ther Endocrinol Metab. 1994;5:155-7.
10
[Agents inhibiting steroid biosynthesis--aminoglutethimide and o,p'-DDD].
Nihon Rinsho. 1974 Nov 10;32(11):3257-61.
本文引用的文献
1
Effects of o,p' DDD on histology and 17-hydroxycorticosteroid output of the dog adrenal cortex.邻对滴滴滴对犬肾上腺皮质组织学及17-羟皮质类固醇分泌量的影响。
Endocrinology. 1959 Jul;65(1):80-6. doi: 10.1210/endo-65-1-80.
2
Effects of aminoglutethimide upon adrenal function and cortisol metabolism in Cushing's syndrome.
J Clin Endocrinol Metab. 1967 Dec;27(12):1657-66. doi: 10.1210/jcem-27-12-1657.
3
Adrenal cortical carcinoma. Results of treatment with o,p'DDD in 138 patients.
Am J Med. 1966 Oct;41(4):581-92. doi: 10.1016/0002-9343(66)90220-8.
4
Adrenal cortical carcinoma. Clinical features of 138 patients.肾上腺皮质癌。138例患者的临床特征。
Am J Med. 1966 Oct;41(4):572-80. doi: 10.1016/0002-9343(66)90219-1.
5
Effects of O,p'DDD and aminoglutethimide on metastatic adrenocortical carcinoma.
Med J Aust. 1969 Apr 19;1(16):809-12.
6
Clinical therapeutics of adrenal disorders.
Am J Med. 1972 Nov;53(5):673-84. doi: 10.1016/0002-9343(72)90162-3.
7
8
Treatment of Cushing's disease. Correction of hypercortisolism by o,p'DDD without induction of aldosterone deficiency.库欣病的治疗。使用邻对滴滴滴纠正高皮质醇血症而不诱发醛固酮缺乏。
N Engl J Med. 1969 Oct 9;281(15):801-5. doi: 10.1056/NEJM196910092811501.
9
[Clinical and biological study of an inhibitor of adrenocortical hormone synthesis: aminoglutethinide].
Ann Endocrinol (Paris). 1968 Mar-Apr;29(2):189-210.
10
Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial.
J Clin Endocrinol Metab. 1967 Sep;27(9):1239-48. doi: 10.1210/jcem-27-9-1239.
Zotero 插件