Majkowski J, Sobieszek A
Physiol Behav. 1975 Feb;14(2):123-31. doi: 10.1016/0031-9384(75)90156-0.
Sensory-specific and modality nonspecific average evoked potentials (AEPs) were recorded from the cortical areas and subcortical structures in two groups of cats: (1) normal cats which after conditioning were subjected to brainstem lesions and reconditioning; (2) cats with brainstem lesions and subsequent conditioning. A new waveshape of the visually evoked potenials developed in the visual cortex in the course of conditioning to light flashes (LF) in both groups of cats. In normal cats, a new component, with a peak latency from 80-100 msec and with reversed polarity, was observed in place of the late, longlasting, component of the preconditioning AEP. The latency of the new component is longer in cats with brainstem lesions. The first signs of waveform modification occurred relatively early in the process of learning, well before the animal learned to react consistently to the conditioned stimulus. Also, there seemed to be no clear relationship between the modified waveshapes of the AEPs and performance level during a particular session of conditioning. The modifications did not depend on habituation to the long-lasting exposure to light flashes presented alone. The new waveshape was preserved to a variable degree after brainstem lesions, that is, reconditioning never started with a potential characteristic for a naive animal. AEPs to licks in the auditory cortex, also changed during conditioning, although this modification was not so evident as in visual responses. In contrast to evident modifications of evoked responses in sensory specific structures during the process of conditiong, there were very small if any, changes in modality nonspecific structures, including brainstem reticular formation. Modality nonspecific responses were obtained from the brainstem reticular formation and motor cortex to light flashes and clicks, from the visual cortex to auditory stimuli and from the auditory cortex to light flashes. Only poorly developed evoked responses could be detected in the motor-sensory cortex during conditioning to light flashes although rhythmic EEG activity related to presentation of the conditioned stimulus (CS) was observed from this arena - thus indicating that they were not the same phenomena.
在两组猫的皮质区域和皮质下结构记录了感觉特异性和模式非特异性平均诱发电位（AEP）：（1）正常猫，在进行条件反射后接受脑干损伤并重新进行条件反射；（2）患有脑干损伤并随后进行条件反射的猫。在两组猫对闪光（LF）进行条件反射的过程中，视觉皮质中出现了一种新的视觉诱发电位波形。在正常猫中，观察到一个新的成分，其峰潜伏期为80 - 100毫秒，极性相反，取代了条件反射前AEP的晚期、持续时间长的成分。脑干损伤的猫中这个新成分的潜伏期更长。波形改变的最初迹象在学习过程中出现得相对较早，远在动物学会对条件刺激做出一致反应之前。此外，在特定的条件反射过程中，AEP的改变波形与表现水平之间似乎没有明显的关系。这些改变并不取决于对单独呈现的长时间闪光的习惯化。脑干损伤后，新波形在不同程度上得以保留，也就是说，重新进行条件反射时，从未出现过未经过训练动物的典型电位特征。听觉皮质对舔舐的AEP在条件反射过程中也发生了变化，尽管这种改变不如视觉反应那么明显。与条件反射过程中感觉特异性结构中诱发电位的明显改变形成对比的是，模式非特异性结构，包括脑干网状结构，即使有变化也非常小。从脑干网状结构和运动皮质记录到了对闪光和点击的模式非特异性反应，从视觉皮质记录到了对听觉刺激的反应，从听觉皮质记录到了对闪光的反应。在对闪光进行条件反射时，在运动感觉皮质中只能检测到发育不良的诱发电位，尽管从这个区域观察到了与条件刺激（CS）呈现相关的节律性脑电图活动——因此表明它们不是同一现象。
