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[保罗·埃尔利希(1854 - 1915)及其在测试首批化学治疗药物时与东欧医生的接触]

[Paul Ehrlich (1854-1915) and his contacts with East European physicians at the time of testing the first chemioterapeutics].

作者信息

Schneck P

机构信息

Institut für Geschichte der Medizin, Universitätsklinikum Charité der Humboldt-Universität zu Berlin.

出版信息

Arch Hist Filoz Med. 1996;59(1):41-8.

Abstract

Among numerous scientific contacts which Paul Ehrlich had with foreign scientists information about his contacts with East European scientists is very limited. The communiqué will deal with some of the particulars concerning Ehrlich's co-operation with physicians from East Europe directly before the practical application of the chemioterapeutics among others he was in touch with the Russians: Georgi N. Gabryczewski, Alexander A. Władimirow and a Finn Julius Iversen. The contacts originated during Robert Koch bacteriological courses at the Institute of Hygiene in Berlin. Only between 1885-1988 at least 11% of participants came from the countries of Eastern Europe. Ehrlich and Gabryczewski correspondence indicates that such a co-operation had already existed in the 90-ties, at the time of the research of a therapeutic influence of aniline dyes like diacetylparaaminophenol and triasid at spirillioza (recurrens). Iversen, a chief physician of Obuchow Hospital in St. Petersburg, was one of the first who after initial tests (Atoxyl, Arsazetin), at Ehrlich's request successfully used 606 preparation in case of spirochaeta infections.

摘要

在保罗·埃尔利希与外国科学家的众多学术交往中,有关他与东欧科学家交往的信息非常有限。本公报将涉及埃尔利希与东欧医生合作的一些具体情况,尤其是在化学疗法实际应用之前,他与俄罗斯人有过接触:格奥尔基·N·加布里采夫斯基、亚历山大·A·弗拉迪米罗夫以及芬兰人尤利乌斯·艾弗森。这些交往始于罗伯特·科赫在柏林卫生研究所举办的细菌学课程。仅在1885年至1888年期间,至少11%的参与者来自东欧国家。埃尔利希与加布里采夫斯基的通信表明,这种合作在19世纪90年代就已存在,当时正在研究二乙酰对氨基酚和三氮烯等苯胺染料对回归热螺旋体病的治疗作用。圣彼得堡奥布霍夫医院的主任医师艾弗森是最早应埃尔利希的要求,在初步试验(阿托克西尔、砷凡纳明)后,成功将606制剂用于治疗螺旋体感染的人之一。

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