脑黄染的新生儿：1875 - 1908年德国核黄疸的发现

Newborn infants with yellow brains: the discovery of kernicterus in Germany, 1875-1908.

作者信息

Sourkes T L

机构信息

Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

出版信息

J Hist Neurosci. 1997 Dec;6(3):325-30. doi: 10.1080/09647049709525718.

DOI:10.1080/09647049709525718

PMID:11619868

Abstract

Kernicterus, described in the period just before Kinnier Wilson's publication of his study of hepatolenticular degeneration, served him as a model of liver dysfunction associated with neurological disorder. The work of the early investigators of kernicterus, especially their descriptions of the pathological changes in the brain, led Wilson to postulate that a hepatotoxin was responsible for the neurological entity that he elucidated.

摘要

核黄疸在金尼尔·威尔逊发表其关于肝豆状核变性的研究之前就已被描述，它为威尔逊提供了一个与神经障碍相关的肝功能障碍模型。早期核黄疸研究者的工作，尤其是他们对大脑病理变化的描述，促使威尔逊推测一种肝毒素是他所阐明的神经病症的病因。