前列腺素E2对离体灌注兔肾动脉周围刺激和去甲肾上腺素升压反应的影响。
Effect of prostaglandin E2 on the pressor response to periarterial stimulation and norepinephrine of the isolated perfused rabbit kidney.
作者信息
Türker R K, Ercan Z S
出版信息
Prostaglandins. 1975 May;9(5):695-701. doi: 10.1016/0090-6980(75)90108-2.
The interaction of prostaglandin E2 (PGE2) and aspirin with the responses to peri-arterial stimulation (PS) and norepinephrine (NE) was studied in the isolated kidney of rabbit perfused through the renal artery at constant flow with Krebs' solution. NE and PS increased vascular perfusion pressure of kidney and caused a contraction on the isolated rabbit aortic strip superfused with the effluent from kidney. Addition of PGE2 to the perfusion medium decreased the PS-induced rise in perfusion pressure without changing the effect of exogenous NE. In contrast, addition of aspirin to the perfusion medium induced a potentiation of the response to PS but not to NE. These results suggest that PGE2 modulates the effect of PS probably by inhibiting the releases of NE from sympathetic nerve endings.
在以恒定流量经肾动脉用 Krebs 溶液灌注的兔离体肾脏中，研究了前列腺素 E2（PGE2）和阿司匹林与动脉周围刺激（PS）反应以及去甲肾上腺素（NE）反应之间的相互作用。NE 和 PS 增加了肾脏的血管灌注压力，并使灌流有肾脏流出液的离体兔主动脉条产生收缩。向灌注介质中添加 PGE2 可降低 PS 诱导的灌注压力升高，而不改变外源性 NE 的作用。相反，向灌注介质中添加阿司匹林可增强对 PS 的反应，但对 NE 无增强作用。这些结果表明，PGE2 可能通过抑制交感神经末梢释放 NE 来调节 PS 的作用。
Zotero 插件