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[拉克尔与欧加农。荷兰的大学实验室与制药行业]

[Laqueur and Organon. The university laboratory and the pharmaceutical industry in the Netherlands].

作者信息

Oudshoorn N

机构信息

Vakgroep Wetenschaps en technologiedynamica UvA, Amsterdam.

出版信息

Gewina. 1999;22(1):12-22.

Abstract

Since the 1970s cooperation between universities and pharmaceutical firms is business as usual. This has not always been the case. The first alliances between academic scientists and the pharmaceutical industry can be traced back to the 1920s. Compared to the U.S. and most other European countries, the creation of networks between the Dutch academy and industry shows a rather peculiar pattern that is illustrative in clarifying how the relationships between scientists and the pharmaceutical companies were built. Dutch scientists could not ally themselves with the pharmaceutical industry, simply because no Dutch pharmaceutical company specialized in organpreparations existed prior to the 1920s. This situation forced scientists to opt for the strongest form of alliance they could create, namely to take part in the founding of a pharmaceutical company. Ernst Laqueur, a professor in pharmacology at the University of Amsterdam, was one of the three founders of Organon, the Dutch pharmaceutical firm that was founded in 1923. Based on an analysis of the early history of sex endocrinology, this paper examines the creation of networks between Laqueur and Organon. The paper concludes that the university laboratory played a crucial role in the development of Organon. Organon was dependent on Laqueurs laboratory for the provision of the required biological essay techniques in order to manufacture standardized hormone products, Moreover, Laqueur mediated all the contacts between Organon and the clinic, required for the clinical testing of hormones and the provision of raw materials for the making of hormones into chemicals and drugs.

摘要

自20世纪70年代以来,大学与制药公司之间的合作已成为常态。但情况并非一直如此。学术科学家与制药行业的首次联盟可以追溯到20世纪20年代。与美国和大多数其他欧洲国家相比,荷兰学术界与产业界之间网络的形成呈现出一种颇为独特的模式,这对于阐明科学家与制药公司之间的关系是如何建立的具有启示意义。荷兰科学家无法与制药行业结盟,仅仅是因为在20世纪20年代之前不存在专门从事器官制剂生产的荷兰制药公司。这种情况迫使科学家选择他们能够建立的最强形式的联盟,即参与一家制药公司的创立。阿姆斯特丹大学药理学教授恩斯特·拉克尔是1923年成立的荷兰制药公司欧加农的三位创始人之一。基于对性内分泌学早期历史的分析,本文考察了拉克尔与欧加农之间网络的形成。本文得出结论,大学实验室在欧加农的发展中发挥了关键作用。欧加农依赖拉克尔的实验室提供所需的生物学检测技术,以便生产标准化的激素产品。此外,拉克尔介导了欧加农与诊所之间的所有联系,这些联系对于激素的临床试验以及将激素制成化学品和药物所需的原材料供应来说是必需的。

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