Gessner P K, Clarke C C
Psychopharmacology (Berl). 1979 Sep;65(1):59-63. doi: 10.1007/BF00491979.
The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted in significantly lower response rates, a significantly larger fraction of time spent in one (mostly cold) drive condition, and significantly lower body temperatures than administration of saline. In a second experiment the animal was automatically returned to the hot-drive condition every 3 min unless it had been exposed to this condition in the previous 0.4 min although otherwise it remained free to alternative drive conditions at will. Under these conditions, meperidine-treated animals also spent significantly more time in cold drive and had significantly lower body temperatures than control animals, in spite of lower response rates. Pretreatment with 4.5 mg/kg tranylcypromine (4 h prior) did not significantly alter the effects of meperidine administration in either experiment.
使用对流热控制器和经过训练可随意交替热驱动条件（将气流从15摄氏度变为45摄氏度，反之亦然）的小鼠，研究了哌替啶对操作性行为体温调节的影响。给予15mg/kg哌替啶导致反应率显著降低，在一种（大多为寒冷）驱动条件下花费的时间比例显著增加，且体温显著低于给予生理盐水时的情况。在第二个实验中，除非动物在之前的0.4分钟内已暴露于热驱动条件下，否则每3分钟会自动返回热驱动条件，不过在其他方面它仍可随意切换驱动条件。在这些条件下，尽管反应率较低，但与对照动物相比，接受哌替啶治疗的动物在寒冷驱动下花费的时间也显著更多，且体温显著更低。在任何一个实验中，预先给予4.5mg/kg反苯环丙胺（提前4小时）均未显著改变给予哌替啶的效果。
