Garrettson L K
Addict Dis. 1975;2(1-2):179-85.
The disposition of phenobarbital in premature infants was assessed by repeated measurement of the serum concentration of unmetabolized drug and the urinary excretion of both phenobarbital and its metabolite, p-hydroxyphenobarbital. Serum elimination rates did not adequately reflect the elimination of total body phenobarbital. A prolonged distributive phase is postulated. The elimination rate of p-hydroxyphenobarbital was constant, suggesting capacity limited kinetics. Slow elimination in serum concentrations which remained in the therapeutic range for several days suggests that short courses of therapy may have prolonged effect in the newborn premature infant.
通过反复测量未代谢药物的血清浓度以及苯巴比妥及其代谢物对羟基苯巴比妥的尿排泄量，评估了苯巴比妥在早产儿体内的处置情况。血清消除率不能充分反映全身苯巴比妥的消除情况。推测存在一个延长的分布期。对羟基苯巴比妥的消除率是恒定的，提示存在容量限制动力学。血清浓度在治疗范围内持续数天的缓慢消除表明，短疗程治疗可能会对新生儿早产儿产生延长的效应。
