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一种双重杂合血红蛋白。一个个体中存在血红蛋白O印尼型和血红蛋白D旁遮普型。

A double heterozygous hemoglobin. Hemoglobin OIndonesia and hemoglobin DPunjab in an individual.

作者信息

Rahbar S, Nowzari G, Poosti M

出版信息

Am J Clin Pathol. 1975 Sep;64(3):416-20. doi: 10.1093/ajcp/64.3.416.

Abstract

During surveys for abnormal hemoglobins in Iran, an individual was found to have four electrophoretically distinct hemoglobins. The abnormality was found only in the father of the propositus, in two of the father's sisters, and in three brothers and sisters of the propositus. Investigations revealed that the four hemoglobin components are the result of a double heterozygosity between an alpha-chain variant (Hb OIndonesia) and a beta-chain variant (Hb DPunjab). The presence of the abnormal hemoglobins was not associated with hemolytic disorders or obvious clinical symptoms.

摘要

在伊朗进行异常血红蛋白调查期间,发现一名个体有四种电泳性质不同的血红蛋白。这种异常仅在先证者的父亲、父亲的两个姐妹以及先证者的三个兄弟姐妹中发现。调查显示,这四种血红蛋白成分是α链变体(Hb 印度尼西亚型)和β链变体(Hb 旁遮普型)之间双重杂合性的结果。异常血红蛋白的存在与溶血性疾病或明显的临床症状无关。

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