Raboch J, Neuwirth J, Starka L
Andrologia. 1975;7(1):77-83. doi: 10.1111/j.1439-0272.1975.tb01231.x.
Clinical, spermiologic and karyologic examinations and determinations of plasmatic testosterone were performed in a group of 105 chromatin-positive patients aged 16 to 45 years. A comparison with a control group of 108 somatosexually well developed and fertile men at the age of 21 to 55 years has established that in the Klinefelter's syndrome the male sex hormone level in the blood was highly significantly lower. Whereas in the control group the male sex hormone values in the blood were dependent on age, it was not possible to prove any dynamic changes in the process of ageing between 21 and 45 years in chromatin-positive patients. A comparison of some phenotypical and laboratory findings in the various chromosomal variants of Klinefelter's syndrome shows that comparatively the least changes were found in patients with a mosaic of 46,XY/47,XXY.
对一组年龄在16至45岁的105名染色质阳性患者进行了临床、精子学、染色体学检查以及血浆睾酮测定。与一组年龄在21至55岁、身体性发育良好且可生育的108名男性组成的对照组进行比较后发现，在克兰费尔特综合征患者中，血液中的雄性激素水平显著降低。在对照组中，血液中的雄性激素值取决于年龄，但在染色质阳性患者中，无法证明21至45岁之间衰老过程中有任何动态变化。对克兰费尔特综合征各种染色体变异类型的一些表型和实验室检查结果进行比较后发现，相对而言，46,XY/47,XXY嵌合体患者的变化最小。
