James D G
J Med Biogr. 1995 Aug;3(3):148-60. doi: 10.1177/096777209500300305.
Sarcoidosis has been recognized for 125 years, but in every generation it makes a chameleon-like change, so updating is needed every so often. In Jonathan Hutchinson's day it was a dermatological curiosity, which gradually evolved into a multisystem disorder associated with bone cysts, and, with the introduction of X-rays, respiratory abnormalities. During the 1960s, epidemiology showed that this disorder, involving all systems of the body, was widely disseminated throughout the world. Each fresh approach, by investigators in different disciplines, has provided a new dimension, particularly in biochemistry and immunology. Each advance in knowledge brings us nearer the enigma which continues to elude us, namely the aetiology of sarcoidosis (Tables 1 and 2). This paper draws attention to the pioneers and personalities of the movement, and records the succession of congresses which have helped to define it worldwide.
结节病已被认识125年了，但每一代它都会发生变色龙般的变化，所以需要时常更新认知。在乔纳森·哈钦森的时代，它只是一种皮肤病学上的罕见病症，后来逐渐演变成一种与骨囊肿相关的多系统疾病，随着X射线的引入，又发现了呼吸异常。在20世纪60年代，流行病学研究表明，这种累及身体所有系统的疾病在全世界广泛传播。不同学科的研究人员采用的每一种新方法都提供了一个新的视角，特别是在生物化学和免疫学方面。知识上的每一次进步都让我们离这个仍在困扰我们的谜团更近一步，即结节病的病因（表1和表2）。本文关注了该领域的先驱者和代表人物，并记录了一系列有助于在全球范围内界定该疾病的大会。
