Sittig N, Davidowa H
Johannes-Mueller-Institute of Physiology, Charité, Faculty of Medicine, Humboldt University Berlin, Tucholskystr. 2, D-10117 Berlin, Germany.
Behav Brain Res. 2001 Oct 15;124(2):137-43. doi: 10.1016/s0166-4328(01)00223-6.
Histamine is known to play a role in the regulation of waking behavior as well as in processes of memory and reinforcement. The striatum and thalamic nuclei as the intralaminar complex and the anterior group can be involved in these functions. Little is known about the action of histamine on neurons of these brain structures. Single unit activity was extracellularly recorded in rats anesthetized with urethane. Firing of anterior and intralaminar thalamic neurons that responded to iontophoretically administered histamine was predominantly reduced (Wilcoxon test (Wt), P<0.05, n=49 and 63, respectively), whereas striatal neurons were mainly activated by the drug (Wt, P<0.05, n=29). Thalamic neurons also significantly reduced the number of burst discharges and the proportion of spikes involved in bursts. The histaminergic effects could be blocked by H1 or H2 receptor antagonists. In conclusion, histamine may control waking behavior also via nonspecific thalamic nuclei and basal ganglia circuits. Through modulation of the transmission in the anterior thalamus it may exert an influence on learning and emotional processes.
众所周知，组胺在清醒行为的调节以及记忆和强化过程中发挥作用。纹状体以及作为板内核复合体和前组的丘脑核可能参与这些功能。关于组胺对这些脑结构神经元的作用知之甚少。在用乌拉坦麻醉的大鼠中细胞外记录单个单位活动。对离子电渗法给予的组胺有反应的丘脑前核和板内核神经元的放电主要减少（分别为威尔科克森检验（Wt），P<0.05，n = 49和63），而纹状体神经元主要被该药物激活（Wt，P<0.05，n = 29）。丘脑神经元还显著减少了爆发性放电的数量以及爆发中涉及的尖峰比例。组胺能效应可被H1或H2受体拮抗剂阻断。总之，组胺也可能通过非特异性丘脑核和基底神经节回路来控制清醒行为。通过调节丘脑前核的传递，它可能对学习和情绪过程产生影响。
