新合成的吡唑衍生物对大鼠甲醛、角叉菜胶和右旋糖酐诱发的急性爪部水肿的影响。

The effects of newly synthesized pyrazole derivatives on formaldehyde-, carrageenan-, and dextran-induced acute paw edema in rats.

作者信息

Süleyman H, Büyükokuroğlu M E

机构信息

Atatürk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey.

出版信息

Biol Pharm Bull. 2001 Oct;24(10):1133-6. doi: 10.1248/bpb.24.1133.

DOI:10.1248/bpb.24.1133

PMID:11642317

Abstract

The antiinflammatory effects of 10 newly synthesized pyrazole derivatives on formaldehyde-induced rat paw edema were investigated. The most effective of them (K-3) was investigated again in dextran- and carrageenan-induced paw edema. In formaldehyde-induced paw edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the edema by 48.9% (p<0.002), 68.7% (p<0.001), and 79.1% (p<0.001), respectively, 3 h after administration. In dextran-induced paw edema, the same dose of K-3 produced 27.1% (p<0.05), 46.8% (p<0.01), and 63.8% (p<0.002) inhibition, respectively. In the carrageenan-induced paw edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4 h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg.

摘要

研究了10种新合成的吡唑衍生物对甲醛诱导的大鼠爪肿胀的抗炎作用。其中最有效的（K-3）在右旋糖酐和角叉菜胶诱导的爪肿胀中再次进行了研究。在甲醛诱导的爪肿胀中，口服K-3 50、100和200 mg/kg，给药3小时后，水肿分别被抑制48.9%（p<0.002）、68.7%（p<0.001）和79.1%（p<0.001）。在右旋糖酐诱导的爪肿胀中，相同剂量的K-3分别产生27.1%（p<0.05）、46.8%（p<0.01）和63.8%（p<0.002）的抑制作用。在角叉菜胶诱导的爪肿胀试验中，K-3 100 mg/kg在4小时后使炎症反应降低了52.0%。急性毒性研究表明，口服剂量高达2500 mg/kg时，K-3无毒。