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一些新型 3-苯基-N-[3-(4-苯哌嗪基)丙基]-1H-吡唑-5-甲酰胺衍生物的合成及抗炎活性。

Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.

机构信息

Organic Chemistry Division-II, Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad 500607, India.

出版信息

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4138-40. doi: 10.1016/j.bmcl.2011.05.105. Epub 2011 Jun 6.

DOI:10.1016/j.bmcl.2011.05.105
PMID:21689936
Abstract

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.

摘要

合成了一系列新的 3-苯基-N-[3-(4-苯基哌嗪-1-基)丙基]-1H-吡唑-5-甲酰胺衍生物，并在体内角叉菜胶诱导的大鼠足肿胀模型中研究了它们的抗炎活性。所有合成的化合物都被发现是有效的抗炎剂。

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